Preparation and preformualation estimation method of floating microsphere of ofloxacin

Floating drug delivery systems are mainly expected to remain buoyant in gastric contents and consequently enhance the bioavailability of drugs Microsphere is loaded with a their outer polymer shells was prepared by novel emulsion-solvent diffusion method. It floated continuously over surface acidic dissolution media containing surfactant for invitro time 12 hours. microspheres ofloxacin were o/w emulsion solvent evaporation technique using Ethyl cellulose polymers order retain body longer period time. Ofloxacin has short half-life 9 hrs. So we microsphere increasing activity.